JAKARTA, Indonesia (CNN) -- A major earthquake in Indonesia killed at least 75 people Wednesday, according to a Red Cross disaster report, citing an official report from the country's vice president.
Earlier in the day an official said the quake toll was at least 21, with hundreds more injured.
Thousands may be trapped by collapsed buildings and houses, said Rustam Pakaya, the head of Ministry of Health's crisis center.
He said 75 people were seriously injured.
The quake caused widespread power and phone outages, making it difficult to assess the scope of the damage.
It struck at around 5 p.m. local time, about 33 miles (53 kilometers) from Padang, the capital city of West Sumatra. Padang is home to more than 800,000 people.
The earthquake, which had a magnitude of 7.6, according to the U.S Geological Survey, caused widespread power and phone outages, making it difficult for authorities and aid organizations to evaluate damage.
"The situation is quite devastating," said Amelia Merrick, the operations director for World Vision Indonesia.
"Bridges have gone down, phone lines are in total disrepair; it's difficult for us to assess the situation," she said. The organization had said it would send assessment teams to the area Thursday morning.
"We know there's no electricity tonight... many of the families will be spending the night outdoors, in pitch black. I'm very afraid of what might happen next," she said, referring to the possibility of aftershocks.
State-run Antara news agency cited Pakaya as saying he had received reports that part of a hospital had collapsed and that people were buried under the debris.
The earthquake was felt in nearby cities, such as Medan and Gengkulu, where people panicked and ran outside in search of higher ground, fearing a tsunami.
But it was also felt as far away as Singapore and Malaysia.
"I did feel the tremor in office today somewhere between 5 - 6 p.m.," said Ratna Osman, who works in a single-story office building in Petaling Jaya, just outside Malaysia's capital Kuala Lumpur.
"I asked [a co-worker] if there's an earthquake somewhere -- either that or I was hallucinating."
"At first, I thought the chair I was sitting on had a screw loose or something," Osman said.
The region is accustomed to earthquakes, and locals have been taught to identify safe places in case of a tsunami, according to Sean Granville-Ross, the Mercy Corps country director for Indonesia. "We hope that preparation is now paying off," he said.
But if many homes have been destroyed, people may be spending the night with no shelter, he said.
Several buildings were damaged, Metro TV reported, and people were seen running out of their homes and toward the hills. One employee of a private company in Jalan Ahmad Yani, told Antara news agency that "everybody panicked with some shouting 'earthquake.'"
TVOne pictures from the scene showed people milling around outside in the city.
Phone lines were apparently down in many parts of Padang. Indonesia's Tempo Interactive, a media outlet based in Jakarta, had trouble reaching its correspondent in the West Sumatra city, according to journalist Purwani Diyah Prabandari.
"I hope it's just the cell phone connection," Prabandari told CNN.
Indonesians trying to find out more about the quake flooded the Internet, including Twitter. Some expressed concern for relatives and friends in Padang.
"Dear God, please send down your angels to hug and protect my grandpa in Padang," said one Twitter post.
The Web site for one of Indonesia's main newspapers, The Jakarta Globe, crashed for a while, partly as a result of the heavy traffic from people trying to find out about the quake, the paper said in a Twitter post.
The Pacific Tsunami Warning Center of the National Oceanic and Atmospheric Administration (NOAA) issued a tsunami watch for Indonesia, India, Thailand and Malaysia, but canceled it soon after.
The temblor did generate a tsunami just under one foot high, the Pacific Tsunami Warning Center said.
On Tuesday, a magnitude 8.0 quake-triggered tsunami killed at least 111 people in the Samoan islands and Tonga. Read latest news on the Samoa quake and tsunami
The tsunami waves swept across a wide swath of the Pacific Ocean, killing dozens and flattening or submerging villages. The dead included 22 in American Samoa, 82 in Samoa and seven in Tonga.
Officials warned that the death toll could rise as rescue workers start to reach outlying villages and discover new casualties.
The U.S. Geological Survey declined to say whether the two quakes were linked.
"The simple answer is we can't speculate on a connection," Carrieann Bedwell of the USGS told CNN. "Both are in highly seismic areas."
The epicenters of the two temblors are about 4,700 miles (7,600 km) apart.